Endogenous mediators of gastrointestinal disease
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Endogenous mediators of gastrointestinal disease

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Published by CRC Press in Boca Raton, Fla .
Written in English


  • Peptic ulcer -- Etiology,
  • Gastric mucosa -- Pathophysiology,
  • Digestive organs -- Secretions

Book details:

Edition Notes

Includes bibliographies and index.

Statementeditor, John L. Wallace.
ContributionsWallace, John L.
The Physical Object
Pagination223 p. :
Number of Pages223
ID Numbers
Open LibraryOL23781187M
ISBN 10084934574

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Endogenous mediators of gastrointestinal disease. Endogenous mediators of gastrointestinal disease. Inflammopharmacology 2, 92–96 (). https://doi Platelet Activate Factor; Acute Phase Protein; Bile Reflux; Endogenous Mediator; Access options Buy single article. Instant access to the full article PDF. US$ Price includes VAT. Also discussed is the role these mediators play in gastrointestinal side effects of drugs (i.e. non-steroidal anti-inflammatory drugs). Also covered are the mechanisms of action of endogenous mediators relative to the the drugs used clinically for the treatment of . Excessive production of prostaglandins, that is hormone-like endogenous mediators of inflammation, is thought to be a causative factor of cellular injury and may ultimately lead to carcinogenesis. Cyclooxygenase (Cox) 1 and 2 enzymes play a substantial role in the biosynthesis of prostaglandins from arachidonic acid as depicted in Scheme Cox . In this volume, experts in this field have contributed chapters on some of the most important of these endogenous mediators, including histamine, prostaglandins, leukotrienes and platelet-activating factor. The potential contribution of these mediators to gastrointestinal disease has been assessed.

This volume places more emphasis on endogenous mediators of gut motility than on drugs used to treat patients with deranged motility. In this respect it resembles most other books on gastroenterology, for while only a relatively small number of drugs are really useful for a rational therapy, a tremendous amount of data is available on neural and hormonal factors regulating . Mediators and drugs in gastrointestinal motility 1: Morphological basis and neurophysiological control: 2: Endogenous and exogenous agents Article (PDF Author: David L Wingate. Return to top MOTILITY. THE ESOPHAGUS: Anatomy and Pressures: Upper Esophageal Sphincter (UES): Skeletal muscle, essentially comprising the cricopharyngeus muscle. Resting pressure = mm Hg to prevent swallowing of air. Muscle tone is neurogenic and depends on CNS neural input from swallowing center to remain active.; Body: Combination of skeletal and . Title: Endogenous Chemical Mediators in Anti-Inflammation and Pro-Resolution VOLUME: 1 ISSUE: 3 Author(s):C. N. Serhan Affiliation:Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Thorn Building for Medical Research, 7th Floor, 75 Francis Street, Boston, MA Keywords:anti-inflammation, platelets, leukocytes, signal Cited by:

1. Author(s): Wallace,John L Title(s): Endogenous mediators of gastrointestinal disease/ editor, John L. Wallace. Country of Publication: United States Publisher. The results reviewed herein implicate a role of LX and their analogs in many common human diseases including airway inflammation, asthma, arthritis, cardiovascular disorders, gastrointestinal. This book saves the reader time-consuming reference to different sources and provides a synoptic view of the essential aspects of prostaglandins and leukotrienes in one volume. These endogenous prostaglandins and leukotrienes play an essential role as cytoprotective agents and inflammation mediators in the pathogenesis of some frequent.   Chemical and Enzymatic Mediators Found in Body Fluids. Fluids produced by the skin include examples of both endogenous and exogenous mediators. Sebaceous glands in the dermis secrete an oil called sebum that is released onto the skin surface through hair follicles.